Urodynamics parameters and Metabolic syndrome: prospective pilot study

Omar Saleh1, Maria Angela Cerruto2, Carolina D Elia3, Mauro Gacci1, Antonio Greco1, Aldo Tosto1, Giovanni Tasso1, Tommaso Cai4, Enrico Finazzi Agro5, Marco Carini1, Sergio Serni1
  • 1 Azienda Ospedaliero-Universitaria Careggi, Dipartimento di Urologia (Firenze)
  • 2 Università di Verona, Dipartimento di Urologia (Verona)
  • 3 Ospedale Civile di Bolzano, Unità di Urologia (Bolzano)
  • 4 Ospedale Santa Chiara, Unità di Urologia (Trento)
  • 5 Università di Roma Tor Vergata, Dipartimento di Urologia (Roma)


Metabolic syndrome (MetS) is a worldwide and complex disorder with a severe socioeconomics impact due to the high rate of morbidity and mortality [1]. Metabolic syndrome (MetS) is defined by the International Diabetes Federation as a “cluster of the most dangerous heart attack” risk factors. MetS would not only increase the risk of cardiovascular disease, but represents a significative risk factor for cancers HPV infection, erectile dysfunction, and death [2-4].Also in urology, a significant amount of epidemiological evidence indicates a possible association between MetS and several disorders like male hypogonadism, erectile dysfunction and infertility. Furthermore male patients with MetS seems to reveal a higher incident of low urinary tract symptoms (LUTS) due to developement of benign prostate enlargement (BPE)[5]. Moreover, in literature have been underlined the correlation between METs and the pathophysiology of overactive bladder (OAB).
The aim of our study was to evaluate the correlation between METs and urodynamic parameters in a cohort of 81 female patients with lower urinary tract symptoms (LUTS).

Materials and Methods

We prospectively enrolled 81 female patients affected by LUTS in two Italian academic centers.
All patients were > 18 yrs and presented a history of LUTS with or without incontinence. Patients with neurologic diseases, oncologic disease, previous radio/chemotherapy or pelvic organ prolapse were excluded from the analysis.
All the patients were evaluated with: urological history, bladder diary, blood values (not older than 6 months) and a complete urogynecological and general examination including waist circumference.
All data were recorded in a database.
All patients underwent urodynamic evaluation according to the ICS Good Urodynamic Practice. Continuous normally distributed variables were reported as mean values and SD; chi square was used to compare categorical data and a p < 0.05 was considered to indicate statistical significance.


According to the IDF Guidelines, 12 female patients was affected by MetS.
Regarding LUTS, 28 pts were affected by stress urinary incontinence and 20 by urge incontinence; mean pads per day/used was 1.8 (Table I).
At urodynamic evaluation, mean cystocapacity was 386.5 cc and first desire presented at 156 cc; 61 pts showed, moreover, a detrusor overactivity.
With regard to preoperative evaluation, presence of prolapse of any type or stress urinary incontinence did not showed a METs correlations (p > 0.05); on the contrary, the presence of urge incontinence was related with METs (p 0.03).

Table I Clinical characteristics of the patients

Clinical data
HDL (mg/dL)
Triglycerids (mg/dL)
Fasting glucose (mg/dL)
Diastolic Press (mm/Hg)
Sistolic pressure (mm/Hg)
Waist (cm)
Urethral lenght (mm)
Volume voided (ml)
First desire (ml)
Normal desire (ml)
Strong desire (ml)
Cysto Capacity (ml)
Q max (ml/sec)
Pad/day (n)
Age (years)


The literature regarding MetS and OAB or LUTS in women is sparse and with limited evidences, but MetS is considered a predictor of lower urinary tract symptoms in female patients.
A recent systematic review suggests, moreover, that there may be important links between MetS and OAB and components of MetS such as obesity [6].
In our pilot study, we observed a correlation between MetS and urge incontinence.
In this pilot study the group size is too small to underline strong evidence but a correlation between OAB wet and MetS could be hypothesized .


In literature MetS is a risk factor for OAB. We observed a correlation between MetS and urge incontinence. Further larger RCT’s are needed to confirm and validate our observations.


1. Isra A, Khurana L. Obesity and the metabolic syndrome in developing countries. J Clin Endocrinol Metab 2008; 93 Supp 1.

2. Corona G, Rastrelli G, Morelli A et al. Hypogonadism and metabolic syndrome. J Endocrinol Invest 2011; 34: 557–67.

3. Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2010; 16: 181–3.

4. Cornier MA, Dabelea D, Hernandez TL et al. The metabolic syndrome. Endocr Rev 2008; 29: 777–822.

5. Mauro Gacci, Giovanni Corona, Linda Vignozzi, Matteo Salvi, Sergio Serni, Cosimo De Nunzio, Andrea Tubaro, Matthias Oelke, Marco Carini and Mario Maggi. Metabolic syndrome and benign prostatic enlargement: a systematic review and meta-analysis. BJU Int 2015; 115: 24–31).

6. Bunn F, Kirby M, Pinkney E, Cardozo L, Chapple C, Chester K, Cruz F, Haab F, Kelleher C, Milsom I, Sievart KD, Tubaro A, Wagg A.Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies.Int J Clin Pract. 2015 Feb;69(2):199-217.